Drug safety and efficacy testing is frequently performed in laboratory animals, with limitations regarding extrapolation to humans. For the development of better translational methods, viable human tissue or cells are preferred over animals and immortalized cell lines, especially since several human (tissue specific) models have become available by recent scientific developments (e.g. models based on human tissue or iPSC derived cells/organoids). However, availability and access to high-quality viable human tissues is a hurdle for many researchers.
Here we present the initiative VitalTissue, a platform that aims to supply surgical residual tissues to researchers in end-user laboratories in a (financial) sustainable and transparent way. The initiators of the project have interviewed stakeholders (e.g. researchers, surgeons, patients) and conducted qualitative interviews and quantitative (online) polls, and conclude that there is a substantial unmet need for various types of human tissue, and that potential donors would generally consent to the use of their left-over tissues after medical procedures. We have addressed the legal, ethical, biosafety and logistic issues involved in the supply chain, and developed protocols for the VitalTissue supply chain regarding criteria for sample specification (tissue and donor inclusion criteria), logistics, and information management. Using these protocols, pilot studies were performed in which residual tissue (skin, liver, gut) were supplied from hospitals to researchers within the
consortium in order to evaluate the (metabolic) viability of the human tissue samples. In conclusion, VitalTissue is a promising initiative for a supply chain of residual human tissue samples, which is widely supported by several stakeholders and organizations, and will be enrolled as soon as financial support has been arranged.
References:
Link to vitaltissue;
Link to zonmw.nl